Three of the most influential leaders in American science—Lewis Von Thaer (Battelle), John Wagner (Idaho National Lab), and Tom Mason (Los Alamos National Lab)—took the stage to discuss the future of U.S. scientific leadership. From energy innovation to national security and advanced research, these panelists offered a rare insider’s view into how government labs are tackling today’s biggest challenges. Their discussion was eye-opening, emphasizing the power of collaboration, cutting-edge technology, and long-term vision in shaping a safer, smarter, and more sustainable world.